Kinematic gait parameters are highly sensitive measures of motor deficits and spinal cord injury in mice subjected to experimental autoimmune encephalomyelitis
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- 作者：Maximillan D.J. Fiandera ; max.fiander@dal.ca" class="auth_mail" title="E-mail the corresponding author ; Nicolas Stifanib ; 1 ; nstifani@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Matthew Nicholsa ; matthew.nichols@dal.ca" class="auth_mail" title="E-mail the corresponding author ; Turgay Akayb ; Turgay.Akay@dal.ca" class="auth_mail" title="E-mail the corresponding author ; George S. Robertsona ; c ; robertgs@dal.ca" class="auth_mail" title="E-mail the corresponding author
- 关键词：Multiple sclerosis ; Disease progressive ; Demyelination ; Functional recovery ; Gait
- 刊名：Behavioural Brain Research
- 出版年：2017
- 出版时间：15 January 2017
- 年：2017
- 卷：317
- 期：Complete
- 页码：95-108
- 全文大小：2128 K
文摘
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Kinematic gait analyses identified movement deficits before the onset of clinical signs in mice subjected to experimental autoimmune encephalomyelitis (EAE).
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Gait deficits were observed in mice with mild EAE that failed to show clinical disease signs or altered rotarod performance.
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Impaired movement of the ankle correlated near perfectly with the degree of white matter loss detected in the spinal cord (r = 0.96).
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Kinematic gait analyses should assist the selection of promising therapeutic candidates for clinical testing.