Using monoclonal antibodies as an international standard for the measurement of anti-adalimumab antibodies
详细信息 查看全文
- 作者：Pauline A. van Schouwenburga ; 1 ; Simone Kruithofa ; Gertjan Wolbinka ; b ; Diana Woutersa ; Theo Rispensa ; t.rispens@sanquin.nl" class="auth_mail" title="E-mail the corresponding author
- 关键词：Adalimumab ; Immunogenicity ; Anti-drug antibodies ; Human monoclonal antibodies ; Anti-idiotype Antibodies
- 刊名：Journal of Pharmaceutical and Biomedical Analysis
- 出版年：2016
- 出版时间：20 February 2016
- 年：2016
- 卷：120
- 期：Complete
- 页码：198-201
- 全文大小：832 K
文摘
- class="listitem" id="list_lis0005">
- class="label">•
International standards for the measurement of ADA are currently lacking.
- class="label">•
Assays are differently influenced by affinity/avidity of ADA.
- class="label">•
Affinity influences measurements of ADA levels, precluding expression as ng/ml.
- class="label">•
Monoclonal/polyclonal standards may not run parallel to ADA from patient sera.
- class="label">•
When selecting a standard, these factors should be considered.