Fine mapping under linkage peaks for symptomatic or asymptomatic outcomes of Leishmania infantum infection in Brazil
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- 作者：Jason L. Weirathera ; 1 ; jason-weirather@uiowa.edu" class="auth_mail" title="E-mail the corresponding author ; Priya Duggalb ; 1 ; pduggal@jhsph.edu" class="auth_mail" title="E-mail the corresponding author ; Eliana L. Nascimentoc ; d ; eltomaz@gmail.com" class="auth_mail" title="E-mail the corresponding author ; etomaz@cb.ufrn.br" class="auth_mail" title="E-mail the corresponding author ; Gloria R. Monteirod ; gloriag74@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; Daniella R. Martinsd ; daniellamartins@cb.ufrn.br" class="auth_mail" title="E-mail the corresponding author ; Henio G. Lacerdac ; d ; heniolacerda@ufrnet.br" class="auth_mail" title="E-mail the corresponding author ; Michaela Fakiolae ; 2 ; mf300@cam.ac.uk" class="auth_mail" title="E-mail the corresponding author ; Jenefer M. Blackwelle ; f ; 1 ; jenefer.blackwell@telethonkids.org.au" class="auth_mail" title="E-mail the corresponding author ; Selma M.B. Jeronimod ; g ; h ; 1 ; smbj@cb.ufrn.br" class="auth_mail" title="E-mail the corresponding author ; Mary E. Wilsona ; i ; j ; k ; 1 ; mary-wilson@uiowa.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Visceral leishmaniasis ; Fine mapping ; Linkage regions ; Tropical disease ; Genetic risk factors
- 刊名：Infection, Genetics and Evolution
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：43
- 期：Complete
- 页码：1-5
- 全文大小：788 K
文摘
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Symptomatic and asymptomatic outcome occur with Leishmania infantum infection.
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High density SNP mapping was undertaken on chromosome 9, 15 and 19.
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LTBP4 on chromosome 19 was associated with symptomatic disease.
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Results confirm regulation of TGF-β as important in disease pathogenesis.