A novel injectable phospholipid gel co-loaded with doxorubicin and bromotetrandrine for resistant breast cancer treatment by intratumoral injection
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- 作者：Jing-Wen Luo ; Ting Zhang ; Quan Zhang ; Xi Cao ; Xin Zeng ; Yao Fu ; Zhi-Rong Zhang ; Tao Gong ; gongtaoy@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Doxorubicin ; Bromotetrandrin ; In situ-forming gel ; Intratumoral injection ; Resistant cancer
- 刊名：Colloids and Surfaces B: Biointerfaces
- 出版年：2016
- 出版时间：1 April 2016
- 年：2016
- 卷：140
- 期：Complete
- 页码：538-547
- 全文大小：3879 K
文摘
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A phospholipids-based in situ-forming gel platform (PG) has been developed.
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Concurrent delivery of doxorubicin (DOX) and bromotetrandrin (W198).
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The adding of oleic acid provides a new strategy to deliver alkaloids via PG.
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Achieved sustained drug release both in vitro and in vivo.
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Eliminated toxicity and improved antitumor efficacy by reversing the multidrug resistance.