Growth/differentiation factor-15 deficiency compromises dopaminergic neuron survival and microglial response in the 6-hydroxydopamine mouse model of Parkinson's disease
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- 作者：Venissa Machadoa ; b ; c ; venissa.machado@sgbm.uni-freiburg.de" class="auth_mail" title="E-mail the corresponding author ; Stefan J.-P. Haase ; stefan.haas@uni-rostock.de" class="auth_mail" title="E-mail the corresponding author ; Oliver von Bohlen und Halbachd ; oliver.vonbohlen@uni-greifswald.de" class="auth_mail" title="E-mail the corresponding author ; Andreas Wreee ; andreas.wree@med.uni-rostock.de" class="auth_mail" title="E-mail the corresponding author ; Kerstin Krieglsteina ; kerstin.krieglstein@anat.uni-freiburg.de" class="auth_mail" title="E-mail the corresponding author ; Klaus Unsickera ; ku39@anat.uni-freiburg.de" class="auth_mail" title="E-mail the corresponding author ; Bjö ; rn Spittaua ; bjoern.spittau@anat.uni-freiburg.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：6-OHDA ; 6-hydroxydopamine ; ABTS ; 2 ; 2&prime ; -azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) ; BSA ; bovine serum albumin ; CNS ; central nervous system ; CPu ; caudate putamen ; CXCL12 ; chemokine (C&ndash ; X&ndash ; C motif) ligand 12 ; CXCR4 ; chemokine (C&ndash ; X&ndash ; C motif) Receptor 4 ; DA ; dopamine ; DAB ; 3 ; 3&prime ; -diaminobenzidine ; DAergic ; dopaminergic ; DAPI ; 4&prime ; 6-diamidino-2-phenylindole ; DMEM/F-12 ; Dulbecco's modified Eagle's medium/Ham's F12 ; DRG ; dorsal root ganglia ; E14 ; embryonic day 1
- 刊名：Neurobiology of Disease
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：88
- 期：Complete
- 页码：1-15
- 全文大小：3780 K
文摘
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Loss of Gdf-15 aggravates 6-OHDA lesion-mediated cell death of DAergic neurons.
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Gdf-15−/− mice exhibit reduced numbers of microglia following 6-OHDA administration.
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Gdf-15−/− mice show a differential cytokine expression pattern post-6-OHDA lesion.
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Gdf-15 mediates lesioned DAergic neuron survival, possibly in a direct neurotrophic supportive manner.