Behavioral toxicity and physiological changes from repeated exposure to fluorene administered orally or intraperitoneally to adult male Wistar rats: A dose-response study
详细信息 查看全文
- 作者：Julie Peiffera ; julie.peiffer@univ-lorraine.fr" class="auth_mail" title="E-mail the corresponding author ; Nathalie Grovab ; Sophie Hidalgoc ; Guillaume Salquè ; breb ; Guido Rychena ; Jean-Franç ; ois Bissonc ; Brice M.R. Appenzellerb ; Henri Schroedera
- 关键词：Fluorene ; Intraperitoneal or oral administration ; Behavior ; Brain and blood concentration levels
- 刊名：Neurotoxicology
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：53
- 期：Complete
- 页码：321-333
- 全文大小：876 K
文摘
- class="listitem" id="list_lis0005">
- class="label">•
Adult male rats were treated intraperitoneally or orally with fluorene at 0, 1, 10 or 100 mg/kg/day during 60 days.
- class="label">•
Lower levels of anxiety were observed in rats treated with 1 and 10 mg/kg/day of fluorene.
- class="label">•
Less significant weight gain and increases in relative liver weight were noticed.
- class="label">•
Higher levels of fluorene and its metabolites were measured in blood and brain of i.p.-treated rats.