A Child’s HLA-DRB1 genotype increases maternal risk of systemic lupus erythematosus
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- 作者：Giovanna I. Cruza ; gcruz@berkeley.edu" class="auth_mail" title="E-mail the corresponding author ; Xiaorong Shaoa ; xshao@berkeley.edu" class="auth_mail" title="E-mail the corresponding author ; Hong Quacha ; hquach@berkeley.edu" class="auth_mail" title="E-mail the corresponding author ; Kimberly A. Hob ; ho.kimberly@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Kirsten Sterbab ; thesterbas@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Janelle A. Noblec ; jnoble@chori.org" class="auth_mail" title="E-mail the corresponding author ; Nikolaos A. Patsopoulosd ; e ; f ; npatsopoulos@rics.bwh.harvard.edu" class="auth_mail" title="E-mail the corresponding author ; Michael P. Buschg ; mbusch@bloodsystems.org" class="auth_mail" title="E-mail the corresponding author ; Darrell J. Triulzih ; DTriulzi@itxm.org" class="auth_mail" title="E-mail the corresponding author ; Wendy S.W. Wongi ; ShukwanWendy.Wong@inova.org" class="auth_mail" title="E-mail the corresponding author ; Benjamin D. Solomoni ; Benjamin.Solomon@inova.org" class="auth_mail" title="E-mail the corresponding author ; John E. Niederhuberi ; John.Niederhuber@inova.org" class="auth_mail" title="E-mail the corresponding author ; Lindsey A. Criswellb ; 1 ; Lindsey.Criswell@ucsf.edu" class="auth_mail" title="E-mail the corresponding author ; Lisa F. Barcellosa ; j ; 1 ; lbarcellos@berkeley.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Systemic lupus erythematosus ; Genetic epidemiology ; Human leukocyte antigen genes ; Pregnancy
- 刊名：Journal of Autoimmunity
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：74
- 期：Complete
- 页码：201-207
- 全文大小：283 K
文摘
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A child’s DRB1 genotype is associated with increased risk of maternal SLE.
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DRB1*04:01 inherited from the father is associated with a 2-fold risk of SLE.
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Risk was only increased among mothers who carry DRB1 *03:01, *15:01 and/or *08:01.