Long Neural Genes Harbor Recurrent DNA Break Clusters in Neural Stem/Progenitor Cells
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- 作者：Pei-Chi Wei1 ; 2 ; 3 ; 4 ; Amelia N. Chang1 ; 2 ; 3 ; 4 ; Jennifer Kao1 ; 2 ; 3 ; Zhou Du1 ; 2 ; 3 ; Robin M. Meyers1 ; 2 ; 3 ; Frederick W. Alt1 ; 2 ; 3 ; alt@enders.tch.harvard.edu" class="auth_mail" title="E-mail the corresponding author ; Bjoern Schwer1 ; 2 ; 3 ; bjoern.schwer@childrens.harvard.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell
- 出版年：2016
- 出版时间：11 February 2016
- 年：2016
- 卷：164
- 期：4
- 页码：644-655
- 全文大小：2372 K
文摘
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27 Recurrent DSB clusters (RDCs) are identified in neural stem/progenitor cells
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All RDCs are within genes, most of which are long, transcribed, and late replicating
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Most RDC genes are involved in synapse function and/or neural cell adhesion
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A nucleotide-resolution view of replication stress-associated fragile sites is provided