Retinoic acid enhances progesterone production via the cAMP/PKA signaling pathway in immature rat granulosa cells
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- 作者：Hiroto Suwa m13702016@gunma-u.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Hiroshi Kishi hrskishi@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Fumiharu Imai fumihimai@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Kohshiro Nakao m12702010@gunma-u.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Takashi Hirakawa tahirakawa@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Takashi Minegishi ; tminegis@gunma-u.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：Retinoic acid ; Granulosa cell ; Progesterone ; Steroidogenic acute regulatory protein ; cAMP ; Protein kinase A
- 刊名：Biochemistry and Biophysics Reports
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：8
- 期：Complete
- 页码：62-67
- 全文大小：889 K
文摘
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atRA upregulated StAR and Cyp11a1 and enhanced progesterone production.
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atRA enhanced intracellular cAMP accumulation and phosphorylation of CREB.
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Inhibition of PKA abolished the stimulatory effects of atRA.
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atRA mediated progesterone synthesis in rat GCs during the early follicle stage.