Altered Cortical Dynamics and Cognitive Function upon Haploinsufficiency of the Autism-Linked Excitatory Synaptic Suppressor MDGA2
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- 作者：Steven A. Connor1 ; 2 ; 9 ; Ina Ammendrup-Johnsen1 ; 9 ; Allen W. Chan1 ; 2 ; 9 ; Yasushi Kishimoto3 ; 9 ; Chiaki Murayama4 ; 5 ; Naokazu Kurihara3 ; Atsushi Tada3 ; Yuan Ge1 ; Hong Lu1 ; Ryan Yan1 ; Jeffrey M. LeDue1 ; Hirotaka Matsumoto5 ; Hiroshi Kiyonari6 ; 7 ; Yutaka Kirino3 ; Fumio Matsuzaki8 ; Toshiharu Suzuki5 ; Timothy H. Murphy1 ; Yu Tian Wang2 ; ytwang@brain.ubc.ca" class="auth_mail" title="E-mail the corresponding author ; Tohru Yamamoto4 ; tohru@med.kagawa-u.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Ann Marie Craig1 ; acraig@mail.ubc.ca" class="auth_mail" title="E-mail the corresponding author
- 刊名：Neuron
- 出版年：2016
- 出版时间：7 September 2016
- 年：2016
- 卷：91
- 期：5
- 页码：1052-1068
- 全文大小：6450 K
文摘
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Autism-linked MDGA2 negatively regulates the NLGN-NRXN synaptic pathway
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Mdga2+/− mice show increased excitatory synapse number and function and altered LTP
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Mdga2+/− mice represent a heterozygous model with an autism-like behavior phenotype
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In vivo imaging reveals enhanced activity and hyperconnectivity in Mdga2+/− cortex