Loading kinetics of 5-fluorouracil onto hydrotalcite and in vitro drug delivery
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- 作者：Qing-Jun Huang ; Hong-Yan Zeng ; hongyanzeng99@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; Wei Zhang ; Bo Feng ; Xiao-Jun Liu ; Heng-Zhi Duan ; Peng-Xuan Ding
- 关键词：Hydrotalcites ; 5-Fluorouracil ; Adsorption kinetics ; Sustained release ; Acid-pretreatment
- 刊名：Journal of the Taiwan Institute of Chemical Engineers
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：60
- 期：Complete
- 页码：525-531
- 全文大小：615 K
文摘
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The pt-LDH carrier was obtained by steeping the LDH in weak acid environment.
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5-FU was successfully intercalated into the pt-LDH by ion-exchange method.
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The loading process was investigated by diffusion kinetics.
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The 5-FU release from the FU/pt-LDH was studied.
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The pt-LDH as a carrier had better release stability.