A possible significant role of zinc and GPR39 zinc sensing receptor in Alzheimer disease and epilepsy

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• 作者：Muhammad Zahid Khan ; ^{mzahidk786@hotmail.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Zinc ; GPR39 receptor ; Alzheimer's disease ; Epilepsy
• 刊名：Biomedicine & Pharmacotherapy
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：79
• 期：Complete
• 页码：263-272
• 全文大小：1472 K

文摘

Zinc the essential trace element, plays a significant role in the brain development and in the proper brain functions at every stage of life. Misbalance of zinc (Zn²⁺) ions in the central nervous system is involved in the pathogenesis of numerous neurodegenerative disorders such as Alzheimer's disease, Depression, and Epilepsy. In brain, Zn²⁺ has been identified as a ligand, capable of activating and inhibiting the receptors including the NMDA-type glutamate receptors (NMDARs), GABA_A receptors, nicotinic acetylcholine receptors (nAChRs), glycine receptors (glyR) and serotonin receptors (5-HT3). Recently GPR39 has been identified as a zinc-specific receptor, widely expressed in brain tissues including the frontal cortex, amygdala, and hippocampus. GPR39, when binding with Zn²⁺ has shown promising therapeutic potentials. This review presents current knowledge regarding the role of GPR39 zinc sensing receptor in brain, with a focus on Alzheimer’s disease and Epilepsy. Although the results are encouraging, further research is needed to clarify zinc and GPR39 role in the treatment of Alzheimer's disease and Epilepsy.