Overexpression of pro-gastrin releasing peptide promotes the cell proliferation and progression in small cell lung cancer
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- 作者：Zhiyun Gonga ; b ; Renquan Lua ; b ; lurenquan@126.com" class="auth_mail" title="E-mail the corresponding author ; Suhong Xiea ; b ; Minglei Jianga ; Kai Liua ; Ran Xiaoa ; Jiabin Shena ; Yanchun Wanga ; Lin Guoa ; b ; guolin500@hotmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Pro-gastrin releasing peptide ; Small cell lung cancer ; Proliferation ; Apoptosis
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：14 October 2016
- 年：2016
- 卷：479
- 期：2
- 页码：312-318
- 全文大小：2272 K
文摘
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ProGRP is overexpressed in the tissues and sera of the patients with SCLC.
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Down-regulation of ProGRP inhibited cell proliferation.
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Inhibition of ProGRP altered cell cycle distribution and triggers the apoptosis of lung cancer cells.