Osteopontin induces autophagy to promote chemo-resistance in human hepatocellular carcinoma cells
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- 作者：Guoke Liua ; 1 ; liugk01@163.com" class="auth_mail" title="E-mail the corresponding author ; Xiaoyu Fanb ; 1 ; fan_xyxy@126.com" class="auth_mail" title="E-mail the corresponding author ; Min Tanga ; 1 ; ttangmin@sina.com" class="auth_mail" title="E-mail the corresponding author ; Rui Chena ; reachy_chen@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; Hao Wanga ; whdoublehai@126.com" class="auth_mail" title="E-mail the corresponding author ; Rongjie Jiaa ; jiarongjie1221@126.com" class="auth_mail" title="E-mail the corresponding author ; Xuyu Zhouc ; zhouxuyuch@163.com" class="auth_mail" title="E-mail the corresponding author ; Wei Jingc ; jingwei7777@163.com" class="auth_mail" title="E-mail the corresponding author ; Huajing Wanga ; jwhuajing@163.com" class="auth_mail" title="E-mail the corresponding author ; Yang Yanga ; bbyy125@163.com" class="auth_mail" title="E-mail the corresponding author ; Fan Yind ; ying2124@sina.com" class="auth_mail" title="E-mail the corresponding author ; Huafeng Weid ; foxp3_smmu@163.com" class="auth_mail" title="E-mail the corresponding author ; Bohua Lia ; bohuali1020@163.com" class="auth_mail" title="E-mail the corresponding author ; Jian Zhaoa ; zhaojian@smmu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Osteopontin ; Autophagy ; FoxO3a ; Chemo-resistance ; Stem-like phenotype
- 刊名：Cancer Letters
- 出版年：2016
- 出版时间：28 December 2016
- 年：2016
- 卷：383
- 期：2
- 页码：171-182
- 全文大小：3615 K
文摘
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Osteopontin (OPN) induces autophagy in hepatocellular carcinoma cells (HCCs) in vitro.
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OPN enhances autophagy via binding with integrin αvβ3 receptor and sustaining FoxO3a stability.
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OPN promotes chemo-resistance and cancer stem cell-like phenotype of HCCs through autophagy.