Synthesis, characterization and anticancer activity studies of ruthenium(II) polypyridyl complexes on A549 cells
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- 作者：Chuan-Chuan Zenga ; Guang-Bin Jianga ; Shang-Hai Laia ; Cheng Zhanga ; Hui Yinb ; huiyin0103@163.com" class="auth_mail" title="E-mail the corresponding author ; Bing Tanga ; Dan Wana ; Yun-Jun Liua ; lyjche@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Ru(II) complex ; Apoptosis ; Cellular uptake ; Cell cycle arrest ; Western blot analysis
- 刊名：Journal of Photochemistry and Photobiology B: Biology
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：161
- 期：Complete
- 页码：295-303
- 全文大小：1574 K
文摘
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Four new ruthenium(II) complexes were synthesized and characterized.
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The cytotoxicity of complexes against BEL-7402, A549, HeLa, MG-63 cells was evaluated.
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The apoptosis, comet assay, cell migration and cellular uptake were studied.
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The cell cycle arrest was investigated by flow cytometry.
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The expression of Bcl-2 family proteins was assayed by western blot analysis.