mTORC1 Is a Major Regulatory Node in the FGF21 Signaling Network in Adipocytes
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- 作者：Annabel Y. Minard1 ; 2 ; Shi-Xiong Tan3 ; 7 ; Pengyi Yang2 ; 4 ; Daniel J. Fazakerley2 ; Westa Domanova2 ; Benjamin L. Parker2 ; Sean J. Humphrey2 ; Raja Jothi5 ; Jacqueline Stö ; ckli2 ; David E. James2 ; 6 ; 8 ; david.james@sydney.edu.au" class="auth_mail" title="E-mail the corresponding author
- 关键词：FGF21 ; mTORC1 ; mTOR ; UCP1 ; phosphoproteomics ; phosphoproteome ; adipocyte ; signaling ; insulin resistance ; obesity
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：27 September 2016
- 年：2016
- 卷：17
- 期：1
- 页码：29-36
- 全文大小：1688 K
文摘
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FGF21 regulates 821 phosphosites on 542 proteins in adipocytes
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FGF21 activates mTORC1 and S6K independently of AKT via MAPK
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FGF21-induced mTORC1 activation was not associated with insulin resistance
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Rapamycin inhibits FGF21-induced UCP1, glucose uptake, and adiponectin secretion