A soluble form of Siglec-9 provides a resistance against Group B Streptococcus (GBS) infection in transgenic mice
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- 作者：Mitsumasa Saitoa ; b ; msaito@med.uoeh-u.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Sayo Yamamotoc ; ysayo@anim.med.kyushu-u.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Kinuyo Ozakic ; k-ozaki@anim.med.kyushu-u.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Yukiko Tomiokad ; ytomi@muses.tottori-u.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Haruka Suyamac ; sharuka@anim.med.kyushu-u.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Masami Morimatsue ; mmorimat@vetmed.hokudai.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Ken-ichi Nishijimaf ; nishijma@nubio.nagoya-u.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Shin-ichi Yoshidab ; syn-ichi@bact.med.kyushu-u.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Etsuro Onoc ; g ; etsuro@anim.med.kyushu-u.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：Soluble Siglec-9 ; Group B Streptococcus ; Antibacterial benefit ; Transgenic mice
- 刊名：Microbial Pathogenesis
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：99
- 期：Complete
- 页码：106-110
- 全文大小：369 K
文摘
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Transgenic mice expressing soluble Siglec-9 showed resistance against GBS.
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Soluble Siglec-9 bound to GBS strains from serotypes Ia, Ib, II, III, IV and V.
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Transgenic mice expressing soluble Siglec-9 eliminated GBS more efficiently.
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Soluble Siglec-9 had an antibacterial benefit against GBS serotype III infection.