Effects of Marsdenia tenacissima polysaccharide on the immune regulation and tumor growth in H22 tumor-bearing mice
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- 作者：Shuang Jianga ; 1 ; jiangshuang_2000@163.com" class="auth_mail" title="E-mail the corresponding author ; Limin Qiub ; 1 ; Yiquan Lic ; Lu Lia ; Xingyun Wanga ; Zhi Liua ; Yan Guoa ; ; Haotian Wangd ; wht@jlu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Marsdenia tenacissima polysaccharide ; Immunity ; Antitumor ; Hepatic carcinoma ; Antioxidant
- 刊名：Carbohydrate Polymers
- 出版年：2016
- 出版时间：10 February 2016
- 年：2016
- 卷：137
- 期：Complete
- 页码：52-58
- 全文大小：1977 K
文摘
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A homogeneous polysaccharide (MTP) was extracted and fractioned from the the dried rattan of Marsdenia tenacissima.
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MTP could improve the immune functions in normal mice.
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MTP could inhibit the growth of tumor and increase the spleen index, thymus index and ALB level in H22 tumor-bearing mice.
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MTP could reduce serum VEGF levels, and increase TNF-α and IL-2 levels in H22 tumor-bearing mice.
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MTP could improve GSH-Px, SOD and CAT activities, and reduce MDA content in liver tissue of H22 tumor-bearing mice.