Structure-activity of antifungal compounds inspired by aminobisabolenes from the sponge Halichondria sp.

详细信息    查看全文

• 作者：Matthew T. Jamison^a ; Jocelyn Macho^a ; ^&dagger ; ; Tadeusz F. Molinski^a ; ^b ; ^{tmolinski@ucsd.edu" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Allylamine ; Antifungal ; Terpenoid ; Synthesis
• 刊名：Bioorganic & Medicinal Chemistry Letters
• 出版年：2016
• 出版时间：1 November 2016
• 年：2016
• 卷：26
• 期：21
• 页码：5244-5246
• 全文大小：516 K

文摘

Structure–activity relationships of the antifungal aminobisabolene natural product, ong class="boldFont">1ong> isolated from Halichondria sp., and synthetic analogs were explored, in parallel with the antidermatophytic allylamine, Terbinafine®, against a panel of pathogenic fungi: Candida spp., Cryptococcus spp. and Trichophyton rubrum. Interpretation of the results suggest different modes of action in antifungal activity for the two classes of compounds.