Crosstalk between the vitamin D receptor (VDR) and miR-214 in regulating SuFu, a hedgehog pathway inhibitor in breast cancer cells
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- 作者：Fatouma Alimiraha ; Xinjian Penga ; Akash Guptaa ; Liang Yuana ; JoEllen Welshb ; Michele Clearyc ; Rajendra G. Mehtaa ; rmehta@iitri.org" class="auth_mail" title="E-mail the corresponding author
- 关键词：Vitamin D receptor (VDR) ; Crosstalk ; Transrepression ; MiR-214 ; Breast cancer ; Hedgehog signaling
- 刊名：Experimental Cell Research
- 出版年：2016
- 出版时间：15 November 2016
- 年：2016
- 卷：349
- 期：1
- 页码：15-22
- 全文大小：960 K
文摘
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An interplay between VDR and miR-214 is investigated in breast cancer cells.
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VDR overexpression in breast cancer cells reduces miR-214 expression levels by 30%.
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miR-214 inhibits VDR expression and vitamin D mediated signaling in breast cancer cells.
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VDR upregulates SuFu expression whereas, miR-214 inhibits SuFu in breast cancer cells.