Apoptotic neurons induce proliferative responses of progenitor cells in the postnatal neocortex
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- 作者：Volodymyr Petrenko ; Jevgenia Mihhailova ; Patrick Salmon ; Jozsef Z. Kiss ; Jozsef.Kiss@unige.ch" class="auth_mail" title="E-mail the corresponding author
- 关键词：BrdU ; bromodeoxyuridine ; cx ; cortex ; DPI ; days post-injection ; DT ; diphtheria toxin ; DTA ; the A-chain of diphtheria toxin ; DTR ; diphtheria toxin receptor ; GFP ; green fluorescent protein ; SVZ ; subventricular zone ; Tred ; turbo red fluorescent protein
- 刊名：Experimental Neurology
- 出版年：2015
- 出版时间：November 2015
- 年：2015
- 卷：273
- 期：Complete
- 页码：126-137
- 全文大小：2881 K
文摘
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New, highly reproducible models of perinatal neuronal ablation are developed.
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Apoptotic neurons induce early glial responses in the developing brain.
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Induced apoptosis triggers proliferation of Sox2 and NG2 progenitor populations.
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Lack of compensatory neurogenesis after neuronal injury in the developing cortex