Molecular mechanisms in lipopolysaccharide-induced pulmonary endothelial barrier dysfunction
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- 作者：Han Liu ; Xiu Yu ; Sulan Yu ; Junping Kou ; junpingkou@cpu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; junpingkou@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Acute lung injury ; Lipopolysaccharide ; Pulmonary endothelium ; Barrier dysfunction ; Hyper-permeability
- 刊名：International Immunopharmacology
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：29
- 期：2
- 页码：937-946
- 全文大小：739 K
文摘
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Pulmonary endothelial barrier dysfunction is involved in a variety of high mortality diseases.
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MLCK, RhoA, calcium, tyrosine kinases, apoptosis are major barrier-disruptive factors.
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Rac1, Cdc42, S1P, cAMP, ARs, PAR1, FoxM1 are major barrier-protective factors.