Recent advances in the engineering of nanosized active pharmaceutical ingredients: Promises and challenges
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- 作者：Waseem Kaialy ; w.kaialy@wlv.ac.uk" class="auth_mail" title="E-mail the corresponding author ; Maen Al Shafiee
- 关键词：AFR ; aerosol flow reactor ; API ; active pharmaceutical ingredient ; ASES ; aerosol solvent extraction system ; AUC ; area under the curve ; BSA ; bovine serum albumin ; CQA ; critical quality attributes ; Cmax ; maximum plasma concentration ; CSD ; colloidal silicon dioxide ; DCP ; dibasic calcium phosphate anhydrous ; DMA ; dimethylacetamide ; DPI ; dry powder inhalers ; DSC ; differential scanning calorimetry ; EPAS ; evaporative precipitation into aqueous solution ; Eq ; equation ; GAS ; gas anti-solvent ; HGAP ; high gr
- 刊名：Advances in Colloid and Interface Science
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：228
- 期：Complete
- 页码：71-91
- 全文大小：1850 K
文摘
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Nanoparticle engineering is a promising tool to resolve many current issues associated with poorly soluble APIs.
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Serious challenges are associated with the preparation of nanosized APIs.
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Main challenges include separating nanosized APIs from surfactants, low yield, contamination with microsized particles, and re-suspending of nanosized APIs after drying.
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The optimization of nanosizing processes might open new horizons in the development of pharmaceutical products.