A review of factors affecting electrostatic charging of pharmaceuticals and adhesive mixtures for inhalation
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- 作者：Waseem Kaialy w.kaialy@wlv.ac.uk" class="auth_mail" title="E-mail the corresponding author waseemkaialy@hotmail.co.uk" class="auth_mail" title="E-mail the corresponding author
- 关键词：AFM ; atomic force microscopy ; BCMS ; bipolar charge measurement system ; BET ; Brunauer ; Emmett and Teller ; BOLAR ; bipolar charge analyser ; CM ; commercial mannitol ; CMR ; charge&ndash ; to&ndash ; mass ratio ; CSR ; charge&ndash ; to&ndash ; surface ratio ; d50% ; median diameter ; DPIs ; dry powder inhalers ; ELPI ; electrostatic low&ndash ; pressure impactor ; Eq ; Equation ; E&ndash ; SPART ; electrical&ndash ; single particle aerodynamic relaxation time equipment ; FPF ; fine particle fraction ; LDV ; laser doppler velocimet
- 刊名：International Journal of Pharmaceutics
- 出版年：2016
- 出版时间：30 April 2016
- 年：2016
- 卷：503
- 期：1-2
- 页码：262-276
- 全文大小：1563 K
文摘
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Charging of pharmaceutical inhalation powders depends on a combination of many interrelated factors.
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Controlling the charge of inhalation powders is crucial in the development of dry powder inhaler products.
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More controlled studies are justified to increase our understanding in charging.
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Efforts to optimize the charge of drug and carrier particles to maximize DPI performance are warranted.