On the effects of blending, physicochemical properties, and their interactions on the performance of carrier-based dry powders for inhalation — A review
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- 作者：Waseem Kaialy ; w.kaialy@wlv.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 关键词：Adhesive mixtures ; Carrier-based dry powder inhaler formulations ; Homogeneity ; Interparticulate forces ; Mixers ; Micromeritic and bulk properties
- 刊名：Advances in Colloid and Interface Science
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：235
- 期：Complete
- 页码：70-89
- 全文大小：2760 K
文摘
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The importance of particle blending in the preparation of adhesive mixtures for inhalation should not be underestimated.
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Significant changes in carrier physicochemical and aerosolisation properties could be induced by blending.
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A degree of controlled blending is inevitably required to achieve a homogeneous and dispersible adhesive mixture.
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More studies are needed to evaluate the influence of blending on the physicochemical and aerosolisation properties of DPIs.
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Some of the inconsistencies reported by different studies may partly be caused by differences in the blending conditions.