Next-generation personalised medicine for high-risk paediatric cancer patients - The INFORM pilot study
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- 作者：Barbara C. Worsta ; b ; c ; 1 ; b.worst@dkfz-heidelberg.de" class="auth_mail" title="E-mail the corresponding author ; Cornelis M. van Tilburgb ; c ; d ; e ; 1 ; cornelis.vantilburg@nct-heidelberg.de" class="auth_mail" title="E-mail the corresponding author ; Gnana Prakash Balasubramanianc ; f ; g ; 1 ; g.balasubramanian@dkfz-heidelberg.de" class="auth_mail" title="E-mail the corresponding author ; Petra Fieselc ; h ; i ; 1 ; Petra.Fiesel@med.uni-heidelberg.de" class="auth_mail" title="E-mail the corresponding author ; Ruth Wittd ; ruth.witt@nct-heidelberg.de" class="auth_mail" title="E-mail the corresponding author ; Angelika Freitagd ; angelika.freitag@nct-heidelberg.de" class="auth_mail" title="E-mail the corresponding author ; Miream Boudalilc ; h ; i ; Miream.Boudalil@med.uni-heidelberg.de" class="auth_mail" title="E-mail the corresponding author ; Christopher Previtij ; christopher.previti@Dkfz-Heidelberg.de" class="auth_mail" title="E-mail the corresponding author ; Stephan Wolfj ; s.wolf@dkfz-heidelberg.de" class="auth_mail" title="E-mail the corresponding author ; Sabine Schmidtj ; sabine.schmidt@dkfz-heidelberg.de" class="auth_mail" title="E-mail the corresponding author ; Sasithorn Chotewutmontrij ; s.chotewutmontri@Dkfz-Heidelberg.de" class="auth_mail" title="E-mail the corresponding author ; Melanie Bewerunge-Hudlerj ; M.Hudler@dkfz-heidelberg.de" class="auth_mail" title="E-mail the corresponding author ; Matthias Schickj ; m.schick@Dkfz-Heidelberg.de" class="auth_mail" title="E-mail the corresponding author ; Matthias Schlesnerc ; k ; m.schlesner@Dkfz-Heidelberg.de" class="auth_mail" title="E-mail the corresponding author ; Barbara Hutterc ; f ; g ; b.hutter@dkfz-heidelberg.de" class="auth_mail" title="E-mail the corresponding author ; Lenka Taylorl ; Lenka.Taylor@med.uni-heidelberg.de" class="auth_mail" title="E-mail the corresponding author ; Tobias Borstm ; Tobias.Borst@uk-erlangen.de" class="auth_mail" title="E-mail the corresponding author ; Christian Suttern ; C.Sutter@med.uni-heidelberg.de" class="auth_mail" title="E-mail the corresponding author ; Claus R. Bartramn ; cr_bartram@med.uni-heidelberg.de" class="auth_mail" title="E-mail the corresponding author ; Till Mildeb ; c ; e ; t.milde@dkfz-heidelberg.de" class="auth_mail" title="E-mail the corresponding author ; Elke Pfaffa ; b ; c ; e.pfaff@dkfz-heidelberg.de" class="auth_mail" title="E-mail the corresponding author ; Andreas E. Kulozikb ; andreas.kulozik@med.uni-heidelberg.de" class="auth_mail" title="E-mail the corresponding author ; Arend von Stackelbergo ; Arend.Stackelberg@charite.de" class="auth_mail" title="E-mail the corresponding author ; Roland Meiselp ; Meisel@med.uni-duesseldorf.de" class="auth_mail" title="E-mail the corresponding author ; Arndt Borkhardtp ; Arndt.Borkhardt@med.uni-duesseldorf.de" class="auth_mail" title="E-mail the corresponding author ; Dirk Reinhardtq ; dirk.reinhardt@uk-essen.de" class="auth_mail" title="E-mail the corresponding author ; Jan-Henning Klusmannr ; Klusmann.Jan-Henning@mh-hannover.de" class="auth_mail" title="E-mail the corresponding author ; Gudrun Fleischhackq ; gudrun.fleischhack@uk-essen.de" class="auth_mail" title="E-mail the corresponding author ; Stephan Tippeltq ; stephan.tippelt@uk-essen.de" class="auth_mail" title="E-mail the corresponding author ; Uta Dirksens ; Uta.Dirksen@ukmuenster.de" class="auth_mail" title="E-mail the corresponding author ; Heribert Jü ; rgenss ; jurgh@ukmuenster.de" class="auth_mail" title="E-mail the corresponding author ; Christof M. Krammt ; christof.kramm@med.uni-goettingen.de" class="auth_mail" title="E-mail the corresponding author ; Andre O. von Buerent ; u ; Andre.vonBuren@hcuge.ch" class="auth_mail" title="E-mail the corresponding author ; Frank Westermannc ; v ; frank.westermann@Dkfz-Heidelberg.de" class="auth_mail" title="E-mail the corresponding author ; Matthias Fischerw ; x ; y ; matthias.fischer@uk-koeln.de" class="auth_mail" title="E-mail the corresponding author ; Birgit Burkhardts ; birgit.burkhardt@ukmuenster.de" class="auth_mail" title="E-mail the corresponding author ; Wilhelm Wö ; ß ; mannz ; wilhelm.woessmann@paediat.med.uni-giessen.de" class="auth_mail" title="E-mail the corresponding author ; Michaela Nathrathaa ; ab ; michaela.nathrath@klinikum-kassel.de" class="auth_mail" title="E-mail the corresponding author ; Stefan S. Bielackac ; s.bielack@klinikum-stuttgart.de" class="auth_mail" title="E-mail the corresponding author ; Michael C. Frü ; hwaldad ; Michael.Fruehwald@klinikum-augsburg.de" class="auth_mail" title="E-mail the corresponding author ; Simone Fuldac ; ae ; Simone.Fulda@kgu.de" class="auth_mail" title="E-mail the corresponding author ; Thomas Klingebielaf ; thomas.klingebiel@kgu.de" class="auth_mail" title="E-mail the corresponding author ; Ewa Koscielniakac ; E.Koscielniak@klinikum-stuttgart.de" class="auth_mail" title="E-mail the corresponding author ; Matthias Schwabc ; ag ; ah ; Matthias.Schwab@ikp-stuttgart.de" class="auth_mail" title="E-mail the corresponding author ; Roman Tremmelag ; ah ; Roman.Tremmel@ikp-stuttgart.de" class="auth_mail" title="E-mail the corresponding author ; Pablo Herná ; iz Drievero ; pablo.hernaiz@charite.de" class="auth_mail" title="E-mail the corresponding author ; Johannes H. Schulteo ; q ; johannes.schulte@charite.de" class="auth_mail" title="E-mail the corresponding author ; Benedikt Brorsc ; f ; g ; b.brors@dkfz-heidelberg.de" class="auth_mail" title="E-mail the corresponding author ; Andreas von Deimlingc ; h ; i ; andreas.vondeimling@dkfz-heidelberg.de" class="auth_mail" title="E-mail the corresponding author ; Peter Lichterc ; ai ; Peter.Lichter@Dkfz-Heidelberg.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：Personalised medicine ; Oncology ; Paediatrics ; Precision medicine ; Molecular targeted therapy ; Deep sequencing ; Cancer ; Sarcoma ; Brain
- 刊名：European Journal of Cancer
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：65
- 期：Complete
- 页码：91-101
- 全文大小：1139 K
文摘
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Germany-wide personalised medicine study for high-risk paediatric cancer patients.
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Comprehensive sequencing and analysis is feasible in clinically relevant time frame.
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Half of patients across entities harbored a reasonable confidence druggable target.
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Cases of clinical response to targeted agents demonstrate proof of principle.
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This model can expand paediatric access to molecular profiling and targeted therapies.