A combinatorial αβ T cell receptor expressed by macrophages in the tumor microenvironment

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• 作者：Tina Fuchs^a ; Martin Hahn^a ; Vladimir Riabov^b ; Shuiping Yin^b ; Julia Kzhyshkowska^b ; Svenja Busch^a ; Kerstin Pü ; llmann^c ; Alexander W. Beham^d ; Michael Neumaier^a ; Wolfgang E. Kaminski^a ; ^e ; ^{wolfgang.kaminski@bioscientia.de" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Macrophages in the tumor microenvironment ; Variable immune receptor ; TCRαβ
• 刊名：Immunobiology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：222
• 期：1
• 页码：39-44
• 全文大小：1225 K

文摘

Recent evidence indicates the presence of macrophage subpopulations that express the TCRαβ in two major inflammatory diseases, tuberculosis and atherosclerosis. Inflammation is also a well-established attribute of cancer progression and macrophages are one of the major immune cells that infiltrate tumors. Here, we demonstrate that the macrophage-TCRαβ is expressed in the tumor microenvironment of human and murine malignancies. We identify TCRαβ⁺ macrophages in each case of four randomly selected distinct human tumor entities. In human tumor tissues, the TCRαβ expressed by macrophages in the tumor microenvironment is a combinatorial and individual-specific immune receptor. Furthermore, we routinely find TCRαβ⁺ macrophage subpopulations in experimental tumors (TS/A, mammary adenocarcinoma) which we induced both in normal mice and mice deficient in the macrophage receptor stabilin-1. Expression of the combinatorial murine tumor macrophage TCRαβ is individual-specific and independent of stabilin-1. These results demonstrate that TCRαβ expression is a characteristic feature of macrophages in the tumor microenvironment and identify an as yet unrecognized flexible element in the macrophage-based host response to tumors.