From mice to men: Murine models of colorectal cancer for use in translational research

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• 作者：Jonathan P. Evans^a ; ^{jpevans@liverpool.ac.uk" class="auth_mail" title="E-mail the corresponding author} ; ^{drjpevans@doctors.org.uk" class="auth_mail" title="E-mail the corresponding author}Author Vitae ; Paul A. Sutton^a ; ^c ; Boleslaw K. Winiarski^a ; Stephen W. Fenwick^b ; Hassan Z. Malik^b ; Dale Vimalachandran^c ; Elizabeth M. Tweedle^a ; Eithne Costello^a ; Daniel H. Palmer^a ; ^d ; B. Kevin Park^a ; Neil R. Kitteringham^a
• 关键词：Colorectal cancer ; Murine models ; Preclinical studies ; Metastases ; Small animal imaging
• 刊名：Critical Reviews in Oncology and Hematology
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：98
• 期：Complete
• 页码：94-105
• 全文大小：1334 K

文摘

Colorectal cancer (CRC) is the third most common carcinoma worldwide and despite advances in treatment, survival for patients with metastatic disease remains poor. With nearly 50% of patients developing metastases, in vivo investigation is essential to improve outcomes for these patients and numerous murine models of CRC have been developed to allow the study of chemoprevention and chemotherapy, in addition to improving our understanding of the pathogenesis of CRC. Selecting the most appropriate murine model for a specific application will maximize the conversion of potential therapies from the laboratory to clinical practice and requires an understanding of the various models available. This review will provide an overview of the murine models currently used in CRC research, discussing the limitations and merits of each and their most relevant application. It is aimed at the developing researcher, acting as a guide to prompt further reading in planning a specific study.