Dihydropyrano [2,3-c] pyrazole: Novel in vitro inhibitors of yeast α-glucosidase
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- 作者：Hamdy Kashtoha ; Munira Taj Muhammadb ; Jalaluddin J.A. Khana ; Saima Rasheedb ; Ajmal Khanb ; Shahnaz Perveenc ; Kulsoom Javaidb ; Atia-tul-Wahabd ; Khalid Mohammed Khanb ; khalid.khan@iccs.edu" class="auth_mail" title="E-mail the corresponding author ; hassaan2@super.net.pk" class="auth_mail" title="E-mail the corresponding author ; M. Iqbal Choudharya ; b ; d ; iqbal.choudhary@iccs.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Dihydropyrano [2 ; 3-c] pyrazole ; α-Glucosidase inhibition ; Post-prandial hyperglycemia ; Diabetes
- 刊名：Bioorganic Chemistry
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：65
- 期：Complete
- 页码：61-72
- 全文大小：2517 K
文摘
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Synthesis of dihydropyrano [2,3-c] pyrazole derivatives.
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In vitro yeast α-glucosidase inhibitory activity.
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Seven compounds i.e. class="boldFont">1, class="boldFont">2, class="boldFont">4, class="boldFont">19, class="boldFont">22, class="boldFont">30, and class="boldFont">33 were found to possess α-glucosidase active.
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Structure–activity relationship has been established.