Synthesis, in vitro α-glucosidase inhibitory activity and molecular docking studies of new thiazole derivatives
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- 作者：Khalid Mohammed Khana ; khalid.khan@iccs.edu" class="auth_mail" title="E-mail the corresponding author ; hassaan2@super.net.pk" class="auth_mail" title="E-mail the corresponding author ; Saira Qurbana ; Uzma Salara ; Muhammad Tahab ; c ; Shafqat Hussaina ; d ; Shahnaz Perveene ; Abdul Hameeda ; Nor Hadiani Ismailc ; d ; Muhammad Riazf ; Abdul Wadoodf
- 关键词：Synthesis ; Thiazole ; In vitro α-glucosidase ; Structure-activity relationship ; In silico study
- 刊名：Bioorganic Chemistry
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：68
- 期：Complete
- 页码：245-258
- 全文大小：3638 K
文摘
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New thiazole derivatives were synthesized via “one pot” multicomponent reaction.
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Synthetic compounds are hybrid of carbohydrazide and thiazole scaffolds.
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Compounds demonstrated α-glucosidase inhibitory properties.
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Molecular docking studies were carried out.
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Compounds may serve as leads for future research.