Transarterial regional hypothermia provides robust neuroprotection in a rat model of permanent middle cerebral artery occlusion with transient collateral hypoperfusion
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- 作者：Kota Kurisu ; Takeo Abumiya ; abumiya@med.hokudai.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Masaki Ito ; Masayuki Gekka ; Toshiya Osanai ; Hideo Shichinohe ; Naoki Nakayama ; Ken Kazumata ; Kiyohiro Houkin
- 关键词：Apoptosis ; Gliosis ; Hypothermia ; Partial reperfusion injury ; Permanent middle cerebral artery occlusion ; Transarterial regional hypothermia
- 刊名：Brain Research
- 出版年：2016
- 出版时间：15 November 2016
- 年：2016
- 卷：1651
- 期：Complete
- 页码：95-103
- 全文大小：5542 K
文摘
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Transarterial regional hypothermia has neuroprotective effects on transient ischemia.
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We used a model of permanent middle cerebral artery occlusion (MCAO) with transient collateral hypoperfusion.
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Cold infusion was neuroprotective for the penumbra in spite of persistence of MCAO.
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The results suggest the wider application of this therapy in clinical settings.