The level of the zinc homeostasis regulating proteins in the brain of rats subjected to olfactory bulbectomy model of depression
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- 作者：Anna Rafaloa ; b ; Monika Zadroznac ; Barbara Nowakc ; Katarzyna Kotarskaa ; Katarzyna Wiatrowskaa ; Bartlomiej Pochwata ; Magdalena Sowa-Kucmaa ; Paulina Misztaka ; c ; Gabriel Nowaka ; c ; Bernadeta Szewczyka ; szewczyk@if-pan.krakow.pl" class="auth_mail" title="E-mail the corresponding author
- 关键词：AMI ; amitriptyline ; GABA ; gamma-aminobutyric acid ; GAPDH ; glyceraldehyde-3-phosphate dehydrogenase ; Hp ; hippocampus ; IHP ; immunohistochemistry ; IR ; immunoreactivity ; MT ; metallothionein ; NMDA ; N-methyl-d-aspartic acid ; NO ; nitric oxide ; OB ; olfactory bulbectomy ; PFC ; prefrontal cortex ; SDS ; sodium dodecyl sulphate ; SLC30A ; Solute Carrier family 30A ; SLC39A ; Solute Carrier family 39A ; SOD1 ; superoxide dismutase ; TGN ; Golgi network ; TRPML1 ; transient receptor potential mucolipin 1 ; TXRF ; total ref
- 刊名：Progress in Neuropsychopharmacology & Biological Psychiatry
- 出版年：2017
- 出版时间：4 January 2017
- 年：2017
- 卷：72
- 期：Complete
- 页码：36-48
- 全文大小：4712 K
文摘
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Olfactory bulbectomy (OB) elevates ZnT1 protein level in the PFC and Hp of rats.
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OB is associated with decreased levels of ZnT3 protein in the PFC.
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OB elevates mRNA and protein levels of MT1 and MT2 in the PFC of rats.