CAIDE Dementia Risk Score and biomarkers of neurodegeneration in memory clinic patients without dementia

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• 作者：Daniela Enache^a ; ^b ; ^{daniela.enache@ki.se" class="auth_mail" title="E-mail the corresponding author} ; Alina Solomon^a ; ^c ; ^d ; Lena Cavallin^e ; ^f ; Ingemar Kå ; reholt^d ; ^g ; Milica Gregoric Kramberger^a ; ^h ; Dag Aarsland^a ; ⁱ ; ^j ; Miia Kivipelto^a ; ^c ; ^d ; ⁱ ; Maria Eriksdotterⁱ ; ^k ; Bengt Winblad^a ; ⁱ ; Vesna Jelicⁱ ; ^k
• 关键词：Mild cognitive impairment ; Subjective cognitive impairment ; CAIDE dementia risk score ; Neurodegeneration ; Amyloid beta ; Tau
• 刊名：Neurobiology of Aging
• 出版年：2016
• 出版时间：June 2016
• 年：2016
• 卷：42
• 期：Complete
• 页码：124-131
• 全文大小：417 K

文摘

The aim of this study was to explore cross-sectional associations between Cardiovascular Risk Factors, Aging and Dementia Study (CAIDE) Dementia Risk Score and dementia-related cerebrospinal fluid and neuroimaging biomarkers in 724 patients without dementia from the Memory Clinic at Karolinska University Hospital, Huddinge, Sweden. We additionally evaluated the score's capacity to predict dementia. Two risk score versions were calculated: one including age, gender, obesity, hyperlipidemia, and hypertension; and one additionally including apolipoprotein E (APOE) ε4 carrier status. Cerebrospinal fluid was analyzed for amyloid β (Aβ), total tau, and phosphorylated tau. Visual assessments of medial temporal lobe atrophy (MTA), global cortical atrophy-frontal subscale, and Fazekas scale for white matter changes (WMC) were performed. Higher CAIDE Dementia Risk Score (version without APOE) was significantly associated with higher total tau, more severe MTA, WMC, and global cortical atrophy-frontal subscale. Higher CAIDE Dementia Risk Score (version with APOE) was associated with reduced Aβ, more severe MTA, and WMC. CAIDE Dementia Risk Score version with APOE seemed to predict dementia better in this memory clinic population with short follow-up than the version without APOE.