Downregulation of FOXO1 mRNA levels predicts treatment failure in patients with endometrial pathology conservatively managed with progestin-containing intrauterine devices

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作者：Henry D. Reyes^a ; ^{henry-reyes@uiowa.edu" class="auth_mail" title="E-mail the corresponding author} ; Matthew J. Carlson^a ; ¹ ; ^{Matthew.Carlson@utsouthwestern.edu" class="auth_mail" title="E-mail the corresponding author} ; Eric J. Devor^a ; ^{eric-devor@uiowa.edu" class="auth_mail" title="E-mail the corresponding author} ; Yuping Zhang^a ; ^{Yuping-zhang@uiowa.edu" class="auth_mail" title="E-mail the corresponding author} ; Kristina W. Thiel^a ; ^{Kristina-thiel@uiowa.edu" class="auth_mail" title="E-mail the corresponding author} ; Megan I. Samuelson^b ; ^{megan-samuelson@uiowa.edu" class="auth_mail" title="E-mail the corresponding author} ; Megan McDonald^a ; ^{megan-e-mcdonald@uiowa.edu" class="auth_mail" title="E-mail the corresponding author} ; Shujie Yang^a ; ^c ; ^{Shujie-yang@uiowa.edu" class="auth_mail" title="E-mail the corresponding author} ; Jean-Marie Stephan^a ; ^{jean-marie-stephan@uiowa.edu" class="auth_mail" title="E-mail the corresponding author} ; Erica C. Savage^b ; ² ; ^{savagee2@ccf.org" class="auth_mail" title="E-mail the corresponding author} ; Donghai Dai^a ; ^{Donghai-dai@uiowa.edu" class="auth_mail" title="E-mail the corresponding author} ; Michael J. Goodheart^a ; ^c ; ^{Michael-goodheart@uiowa.edu" class="auth_mail" title="E-mail the corresponding author} ; Kimberly K. Leslie^a ; ^c ; ^{Kimbery-Leslie@uiowa.edu" class="auth_mail" title="E-mail the corresponding author}
关键词：Progestin-containing intrauterine devices ; Progesterone receptor ; FOXO1 ; Endometrial hyperplasia ; Endometrial cancer
刊名：Gynecologic Oncology
出版年：2016
出版时间：January 2016
年：2016
卷：140
期：1
页码：152-160
全文大小：1789 K

文摘

class="label">•: We analyzed hormone receptor levels/activity following progestin-containing IUD.
class="label">•: PR target gene FOXO1 was significantly downregulated in patients who progressed.
class="label">•: FOXO1 mRNA levels may reflect PR function and response to progestin-based therapy.

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