Dominant mechanisms of primary resistance differ from dominant mechanisms of secondary resistance to targeted therapies
详细信息 查看全文
- 作者：Ksenija Asić ksenija.asic@gmail.com" class="auth_mail" title="E-mail the corresponding authorAuthor Vitae
- 关键词：Cancer therapy ; Targeted therapy ; Resistance mechanisms ; Intrinsic resistance ; Acquired resistance ; Trastuzumab
- 刊名：Critical Reviews in Oncology and Hematology
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：97
- 期：Complete
- 页码：178-196
- 全文大小：2063 K
文摘
- class="listitem" id="list_lis0005">
- class="label">•
Intrinsic resistance alterations are dominantly located downstream or upstream of a targeted protein.
- class="label">•
Acquired resistance alterations dominantly involve lesions in a targeted protein or target-like proteins.
- class="label">•
Intrinsic resistance evolves as a stochastic process early during tumorogenesis.
- class="label">•
Acquired resistance evolves as a therapy-directed and adaptive selection of alterations.
- class="label">•
Intrinsic and acquired resistance alterations should be pursued on a different panel of biomarkers.