Generation and characterization of a unique panel of anti-adalimumab specific antibodies and their application in therapeutic drug monitoring assays
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- 作者：Sumin Biana ; 1 ; Thomas Van Stappena ; 1 ; Filip Baertb ; Griet Compernollea ; Els Brouwersa ; Sophie Topsa ; Annick de Vriesc ; Theo Rispensd ; Jeroen Lammertyne ; Sé ; verine Vermeiref ; Ann Gilsa ; ann.gils@pharm.kuleuven.be" class="auth_mail" title="E-mail the corresponding author
- 关键词：MA ; monoclonal antibody ; MA-ADM ; monoclonal antibodies towards adalimumab ; TNFα ; tumor necrosis factor-alpha ; TDM ; Therapeutic drug monitoring ; PCA ; Principal component analysis
- 刊名：Journal of Pharmaceutical and Biomedical Analysis
- 出版年：2016
- 出版时间：5 June 2016
- 年：2016
- 卷：125
- 期：Complete
- 页码：62-67
- 全文大小：705 K
文摘
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Ten highly specific monoclonal antibodies towards adalimumab were generated.
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Two adalimumab ELISAs were developed, showed equal characteristics and had excellent agreement with two available ELISAs.
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Comparative studies using different adalimumab assays will facilitate implementation of treatment algorithms.