Deiodinase knockdown affects zebrafish eye development at the level of gene expression, morphology and function
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- 作者：Anne M. Houbrechtsa ; 1 ; Lucia Vergauwenb ; 1 ; Enise Bagcib ; c ; Jolien Van houckea ; Marjolein Heijlena ; Bernard Kulemekad ; David R. Hyded ; Dries Knapenb ; Veerle M. Darrasa ; veerle.darras@bio.kuleuven.be" class="auth_mail" title="E-mail the corresponding author
- 关键词：Thyroid hormone ; Deiodinase ; Morpholino knockdown ; Zebrafish ; Development ; Retina
- 刊名：Molecular and Cellular Endocrinology
- 出版年：2016
- 出版时间：15 March 2016
- 年：2016
- 卷：424
- 期：Complete
- 页码：81-93
- 全文大小：2885 K
文摘
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We studied the effect of deiodinase knockdown on zebrafish retinal development.
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Defects are most prominent after knockdown of the inactivating deiodinase D3b.
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Transcriptome analysis shows a clear effect on phototransduction and retinoid recycling.
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Morphological defects include reduced eye size and photoreceptor number.
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D3b knockdown leads to functional visual impairments.