H3K27me3 Does Not Orchestrate the Expression of Lineage-Specific Markers in hESC-Derived Hepatocytes In Vitro
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- 作者：Jolien Vanhove1 ; 5 ; jolien.vanhove@med.kuleuven.be" class="auth_mail" title="E-mail the corresponding author ; Mariaelena Pistoni1 ; 5 ; mariaelena.pistoni@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Marc Welters1 ; Kristel Eggermont1 ; Veerle Vanslembrouck1 ; Nicky Helsen1 ; Ruben Boon1 ; Mustapha Najimi2 ; Etienne Sokal2 ; Philippe Collas3 ; J. Willem Voncken4 ; Catherine M. Verfaillie1
- 刊名：Stem Cell Reports
- 出版年：2016
- 出版时间：9 August 2016
- 年：2016
- 卷：7
- 期：2
- 页码：192-206
- 全文大小：3831 K
文摘
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Epigenetic studies to understand hepatocyte differentiation from human PSC
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Dynamics in histone profile correlate with alterations in gene transcription
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hESC-derived HLCs have higher H3K27me3 mark at regulatory regions compared with PHHs
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Reducing H3K27me3 by EZH2 inhibition did not improve hepatocyte differentiation