Synthesis of the biotinylated anti-HIV compound BMMP and the target identification study

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• 作者：Masahiro Kamo^a ; ^{141y1023@st.kumamoto-u.ac.jp" class="auth_mail" title="E-mail the corresponding author} ; Hiroshi Tateishi^a ; ^{155y2008@st.kumamoto-u.ac.jp" class="auth_mail" title="E-mail the corresponding author} ; Ryoko Koga^a ; ^{kk1205@kumamoto-u.ac.jp" class="auth_mail" title="E-mail the corresponding author} ; Yoshinari Okamoto^a ; ^{okamoto@gpo.kumamoto-u.ac.jp" class="auth_mail" title="E-mail the corresponding author} ; Masami Otsuka^a ; ^{motsuka@gpo.kumamoto-u.ac.jp" class="auth_mail" title="E-mail the corresponding author} ; Mikako Fujita^b ; ^{mfujita@kumamoto-u.ac.jp" class="auth_mail" title="E-mail the corresponding author}
• 关键词：BMMP ; Biotin ; HIV-1 ; Pr55Gag ; CA
• 刊名：Bioorganic & Medicinal Chemistry Letters
• 出版年：2016
• 出版时间：1 January 2016
• 年：2016
• 卷：26
• 期：1
• 页码：43-45
• 全文大小：336 K

文摘

BMMP [2-(benzothiazol-2-ylmethylthio)-4-methylpyrimidine], an inhibitor of HIV-1 replication, was linked to biotin to study the interaction with the presumed target, HIV-1 Pr55^Gag or CA, by means of surface plasmon resonance. The synthesized Biotin–BMMP inhibited HIV-1 replication to a similar extent as BMMP alone, but did not interact with Pr55^Gag or CA, suggesting that BMMP exerts its activity by a different mechanism.