We generated transgenic mice expressing a soluble nectin-2 (hNectin-2Ig Tg).
hNectin-2Ig Tg exhibited abnormal formation of zymogen granules.
Abnormal proteins were accumulated in dilated ER of acinar cells of hNectin-2Ig Tg.
hNectin-2Ig Tg is new animal model for exocrine defects associated with ER stress.