Identification of CD177 as the most dysregulated parameter in a microarray study of purified neutrophils from septic shock patients
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- 作者：Julie Demareta ; b ; julie.demaret@chu-lyon.fr" class="auth_mail" title="E-mail the corresponding author ; Fabienne Veneta ; b ; fabienne.venet@chu-lyon.fr" class="auth_mail" title="E-mail the corresponding author ; Jonathan Plassaisc ; 1 ; jonathan.plassais@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Marie-Angé ; lique Cazalisc ; marie-angelique.cazalis@biomerieux.com" class="auth_mail" title="E-mail the corresponding author ; Hé ; lè ; ne Vallind ; helene.vallin@chu-lyon.fr" class="auth_mail" title="E-mail the corresponding author ; Arnaud Friggerid ; arnaud.friggeri@chu-lyon.fr" class="auth_mail" title="E-mail the corresponding author ; Alain Lepaped ; alain.lepape@chu-lyon.fr" class="auth_mail" title="E-mail the corresponding author ; Thomas Rimmelé ; e ; thomas.rimmele@chu-lyon.fr" class="auth_mail" title="E-mail the corresponding author ; Julien Textorisc ; e ; julien.textoris@biomerieux.com" class="auth_mail" title="E-mail the corresponding author ; Guillaume Monnereta ; b ; guillaume.monneret@chu-lyon.fr" class="auth_mail" title="E-mail the corresponding author (Prof.)
- 关键词：A647 ; Alexa Fluor-647 ; APC ; Allophycocyanin ; DNA ; Deoxyribonucleic acid ; EDTA ; Ethylenediaminetetraacetic acid ; G-CSF ; Granulocyte-Colony Stimulating Factor ; HIV ; Human immunodeficiency virus ; ICU ; Intensive Care Units ; IQR ; interquartile range ; MDSC ; Myeloid-Derived Suppressor Cells ; MFI ; Mean of fluorescence intensity ; mHLA-DR ; Human Leucocyte Antigen-DR expressed on monocytes ; PC7 ; PE-Cyanin 7 ; PE ; Phycoerythrin ; RNA ; Ribonucleic acid ; ROS ; Reactive Oxygen Species ; SAPS II ; Simplified Acute P
- 刊名：Immunology Letters
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：178
- 期：Complete
- 页码：122-130
- 全文大小：1986 K
文摘
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There is a differential gene expression of purified neutrophils from septic shock patients when compared to healthy controls.
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CD177 appears as the most dysregulated parameter between both groups.
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Increased expression of CD177 in septic shock patients’ neutrophils is confirmed at protein level by flow cytometry.
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A negative correlation exists between expressions of CD10 and CD177.