Response rate of initial conventional treatments, disease course, and related factors of patients with adult-onset Still's disease: Data from a large multicenter cohort

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作者：Umut Kalyoncu^a ; ^{umut.kalyoncu@yahoo.com" class="auth_mail" title="E-mail the corresponding author} ; Dilek Solmaz^b ; ^{drdileksolmaz@yahoo.com" class="auth_mail" title="E-mail the corresponding author} ; Hakan Emmungil^c ; ^{emmungil@mynet.com" class="auth_mail" title="E-mail the corresponding author} ; Ayten Yazici^d ; ^{burakdefy@hotmail.com" class="auth_mail" title="E-mail the corresponding author} ; Timucin Kasifoglu^e ; ^{tkas@mtet.com" class="auth_mail" title="E-mail the corresponding author} ; Gezmiş Kimyon^f ; ^{gkimyon@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Ayşe Balkarli^g ; ^{drayseayan@yahoo.com.tr" class="auth_mail" title="E-mail the corresponding author} ; Cemal Bes^h ; ^{cemalbes@hotmail.com" class="auth_mail" title="E-mail the corresponding author} ; Mustafa Ozmenⁱ ; ^{drmozmen@yahoo.com" class="auth_mail" title="E-mail the corresponding author} ; Fatma Alibaz-Oner^j ; ^{falibaz@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Sü ; kran Erten^k ; ^{sukranerten@yahoo.com" class="auth_mail" title="E-mail the corresponding author} ; Yonca Cagatay^l ; ^{yoncacagatay@yahoo.com" class="auth_mail" title="E-mail the corresponding author} ; Gö ; zde Yıldırım Cetin^m ; ^{gozdeyildirimcetin@yahoo.com" class="auth_mail" title="E-mail the corresponding author} ; Sedat Yilmazⁿ ; ^{drsy75@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Fatih Yildiz^o ; ^{drfatih75@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Omer Nuri Pamuk^p ; ^{omernpamuk@yahoo.com" class="auth_mail" title="E-mail the corresponding author} ; Orhan Kucuksahin^q ; ^{orhankcs@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Levent Kilic^a ; ^{drleventkilic@yahoo.com" class="auth_mail" title="E-mail the corresponding author} ; Veli Yazisiz^r ; ^{drveliyazisiz60@hotmail.com" class="auth_mail" title="E-mail the corresponding author} ; Omer Karadag^a ; ^{omerk@hacettepe.edu.tr" class="auth_mail" title="E-mail the corresponding author} ; Sü ; leyman Serdar Koca^s ; ^{kocassk@yahoo.com" class="auth_mail" title="E-mail the corresponding author} ; Mutlu Hayran^t ; ^{mhayran@hacettepe.edu.tr" class="auth_mail" title="E-mail the corresponding author} ; Servet Akar^b ; ^{servet.akar@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Kenan Aksu^c ; ^{kenan.aksu@ege.edu.tr" class="auth_mail" title="E-mail the corresponding author} ; Nurullah Akkoc^b ; ^{nurullah.akkoc@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Gokhan Keser^c ; ^{agkkeser@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Emel Gonullu^e ; ^{emelorge@yahoo.com" class="auth_mail" title="E-mail the corresponding author} ; Bunyamin Kisacik^f ; ^{bunyamin.kisacik@yahoo.com" class="auth_mail" title="E-mail the corresponding author} ; Ahmet Mesut Onat^f ; ^{ahmetmesutonat@yahoo.com" class="auth_mail" title="E-mail the corresponding author} ; Mehmet Soy^h ; ^{mhmtsoy@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Nevsun Inanc^j ; ^{inanc.nevsun@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Haner Direskeneli^j ; ^{hanerdireskeneli@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Mehmet Sayarlioglu^m ; ^{sayarli@hotmail.com" class="auth_mail" title="E-mail the corresponding author} ; Eren Erken^o ; ^{eerken@cu.edu.tr" class="auth_mail" title="E-mail the corresponding author} ; Murat Turgay^q ; ^{tmturgay@hotmail.com" class="auth_mail" title="E-mail the corresponding author} ; Ayse Cefle^d ; ^{acefle@hotmail.com" class="auth_mail" title="E-mail the corresponding author} ; Ihsan Ertenli^a ; ^{iertenli@hacettepe.edu.tr" class="auth_mail" title="E-mail the corresponding author} ; Salih Payⁿ ; ^{drsalihpay@gmail.com" class="auth_mail" title="E-mail the corresponding author}
关键词：Adult-onset Still's disease ; Disease modifying anti-rheumatic drugs ; Disease pattern ; Remission
刊名：Journal of Autoimmunity
出版年：2016
出版时间：May 2016
年：2016
卷：69
期：Complete
页码：59-63
全文大小：253 K

文摘

class="label">•: Uncertainties in the diagnosis and treatment of adult onset Still's (AOSD) disease needs large comprehensive data.
class="label">•: Induction of remission was mostly achieved with moderate/high doses of corticosteroids and methotrexate/hydroxychloroquine.
class="label">•: Biological agents were needed in a small group of patients, and were effective in patients resistant to other drugs.
class="label">•: Delayed diagnosis of more than 6 months and failure to remission with initial treatment related with chronic disease course.

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