Uncertainties in the diagnosis and treatment of adult onset Still's (AOSD) disease needs large comprehensive data.
Induction of remission was mostly achieved with moderate/high doses of corticosteroids and methotrexate/hydroxychloroquine.
Biological agents were needed in a small group of patients, and were effective in patients resistant to other drugs.
Delayed diagnosis of more than 6 months and failure to remission with initial treatment related with chronic disease course.