Sleep and respiratory sleep disorders in idiopathic pulmonary fibrosis

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• 作者：Giulia Milioli^a ; ^{giulia.milioli@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Marcello Bosi^b ; Venerino Poletti^b ; Sara Tomassetti^b ; Andrea Grassi^a ; Silvia Riccardi^a ; Mario Giovanni Terzano^a ; Liborio Parrino^a
• 关键词：Idiopathic pulmonary fibrosis ; Sleep-related breathing disorders ; Sleep
• 刊名：Sleep Medicine Reviews
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：26
• 期：Complete
• 页码：57-63
• 全文大小：289 K

文摘

Idiopathic pulmonary fibrosis (IPF) is an interstitial lung disease (ILD) characterized by inflammation and progressive scarring of the lung parenchyma. IPF profoundly affects the quality of life (QoL) and fatigue is a frequently disabling symptom. The cause of fatigue is not well understood but patients with IPF often report extremely poor sleep quality and sleep-related breathing disorders (SRBD) that correlate with QoL.

IPF patients present alterations in sleep architecture, including decreased sleep efficiency, slow wave sleep and rapid eye movement (REM) sleep, and increased sleep fragmentation. Moreover, sleep related hypoventilation during the vulnerable REM sleep period and obstructive sleep apnea-hypopnea syndrome (OSAHS) are frequent, but remain usually underdiagnosed. These SRBD in IPF are associated with alterations of the sleep structure, reduction of QoL and increased risk of mortality.

In the absence of an effective therapy for IPF, optimizing the QoL could become the primary therapeutic goal. In this perspective the diagnosis and treatment of SRBD could significantly improve the QoL of IPF patients.