Elevated HMGA2 expression is associated with cancer aggressiveness and predicts poor outcome in breast cancer
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- 作者：Jingjing Wua ; 1 ; Shizhen Zhangb ; c ; 1 ; Jinlan Shanb ; c ; Zujian Hud ; Xiyong Liue ; Lirong Chenc ; f ; Xingchang Reng ; Lifang Yaof ; Hongqiang Shenga ; Ling Lih ; David Anni ; Yun Yenj ; yyen@tmu.edu.tw" class="auth_mail" title="E-mail the corresponding author ; Jian Wangb ; c ; wangjian519@zju.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Xiaochen Wangb ; c ; wangxiaochen@zju.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：High mobility group AT-hook 2 ; Breast cancer ; Tumor progression ; Prognostic biomarker
- 刊名：Cancer Letters
- 出版年：2016
- 出版时间：1 July 2016
- 年：2016
- 卷：376
- 期：2
- 页码：284-292
- 全文大小：3157 K
文摘
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HMGA2 expression positively correlates with histological grade of breast cancer.
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HMGA2 acts as an independent adverse predictor for breast cancer patients.
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GSEA indicates that HMGA2 is associated with metaplastic and mesenchymal phenotype.
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HMGA2 enhances the migration and invasion of BC cells through inducing EMT.
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HMGA2 protects BC cells against doxorubicin by stimulating P53 phosphorylation.