Role of Sirtuin3 in high glucose-induced apoptosis in renal tubular epithelial cells
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- 作者：Xiaocui Jiao ; Ying Li ; liyinghebei@126.com" class="auth_mail" title="E-mail the corresponding author ; Tao Zhang ; Maodong Liu ; Yanqing Chi
- 关键词：Sirtuin3 ; High glucose ; Renal tubular epithelial cell ; Oxidative stress ; Apoptosis
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：18 November 2016
- 年：2016
- 卷：480
- 期：3
- 页码：387-393
- 全文大小：1400 K
文摘
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HG decreases the expression of Sirt3 in a time-dependent manner.
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Overexpression of Sirt3 reduces HG-induced oxidative stress and apoptosis.
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Overexpression of Sirt3 exerts its anti-apoptotic effect by regulating ROS-sensitive Akt/FoxO signaling pathway.