Apelin attenuates postburn sepsis via a phosphatidylinositol 3-kinase/protein kinase B dependent mechanism: A randomized animal study
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- 作者：Keqin Luo ; keqinluodoc@126.com" class="auth_mail" title="E-mail the corresponding author ; Huibao Long longhuibao3hhsa@163.com" class="auth_mail" title="E-mail the corresponding author ; Bincan Xu xubincan42yae@yeah.net" class="auth_mail" title="E-mail the corresponding author ; Yanling Luo luoyanling45bs@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Burn ; Sepsis ; Apelin ; Inflammation ; PI3K/Akt
- 刊名：International Journal of Surgery
- 出版年：2015
- 出版时间：September 2015
- 年：2015
- 卷：21
- 期：Complete
- 页码：22-27
- 全文大小：801 K
文摘
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Burn and burn sepsis induce significantly decreased apelin/APJ expression.
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Apelin reduces inflammatory response and promotes survival after burn sepsis.
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The effect of apelin on burn sepsis is PI3K/Akt dependent.