Full trans-activation mediated by the immediate-early protein of equine herpesvirus 1 requires a consensus TATA box, but not its cognate binding sequence
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- 作者：Seong K. Kim ; skim1@lsuhsc.edu" class="auth_mail" title="E-mail the corresponding author ; Akhalesh K. Shakya ; Dennis J. O&rsquo ; Callaghan
- 关键词：Equine herpesvirus 1 ; Immediate-early protein ; TATA box ; IEP-binding sequence (IEBS) ; TBP ; TFIIA ; Sp1
- 刊名：Virus Research
- 出版年：2016
- 出版时间：4 January 2016
- 年：2016
- 卷：211
- 期：Complete
- 页码：222-232
- 全文大小：2626 K
文摘
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We examine the role of cis-acting sequences of the viral promoters in IEP-mediated trans-activation.
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The IEP trans-activated the viral promoters in a TATA motif-dependent manner.
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The IEP efficiently trans-activated the promoters lacking the IEP-binding sequences (IEBS).
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IEP-mediated full trans-activation requires a consensus TATA box of core promoters, but not its cognate sequence binding.