Bacterial lipopolyssacharide (LPS) stimulates PI3K pathway in hypothalamic LepR expressing cells.
LPS-induced hypophagia is prevented by central PI3K inhibition.
PI3K p110α subunit in LepR cells is not required for LPS-induced hypophagia.
PI3K p110α and p110β double deletion in LepR cells prevents LPS-induced hypophagia.