CCL2 mediates the circadian response to low dose endotoxin
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- 作者：José ; M. Duharta ; 1 ; Lucila Brocardoa ; 2 ; Malena L. Mul Fedelea ; Angelo Guglielmottib ; Diego A. Golombeka ; dgolombek@unq.edu.ar" class="auth_mail" title="E-mail the corresponding author
- 关键词：Circadian ; Suprachiasmatic ; Ccl2 ; Ccr2 ; Chemokine ; Lipopolysaccharide ; Immune ; Bindarit
- 刊名：Neuropharmacology
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：108
- 期：Complete
- 页码：373-381
- 全文大小：2113 K
文摘
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The CCL2 receptor, CCR2, is present in the Suprachiasmatic nuclei of mice.
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Both Ccl2 and Ccr2 shows daily rhythms in expression in SCN tissue.
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CCL2 administration to the SCN region can phase-shift the circadian clock.
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Ccl2 inhibition ameliorates the circadian outcome of peripheral immune activation.