Structure and Functional Characterization of Human Aspartate Transcarbamoylase, the Target of the Anti-tumoral Drug PALA
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- 作者：Alba Ruiz-Ramos1 ; Adriá ; n Velá ; zquez-Campoy2 ; 3 ; 4 ; 5 ; Araceli Grande-Garcí ; a1 ; Marí ; a Moreno-Morcillo1 ; Santiago Ramó ; n-Maiques1 ; sramon@cnio.es" class="auth_mail" title="E-mail the corresponding author
- 刊名：Structure
- 出版年：2016
- 出版时间：6 July 2016
- 年：2016
- 卷：24
- 期：7
- 页码：1081-1094
- 全文大小：5929 K
文摘
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Crystal structures of human ATCase domain free and bound to CP or PALA were determined
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Human ATCase is a catalytic homotrimer with three cooperative active sites
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Only two active sites show high affinity for the binding of the anti-tumoral drug PALA
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R2024 and loop H1-S2 regulate and transmit conformational changes between subunits